Description

Gsk-3 Inhibitor Xv CAS NO 936112-69-5 is a potent and selective small molecule inhibitor of glycogen synthase kinase-3 (GSK-3), a key enzyme involved in numerous cellular signaling pathways. This compound is a critical research tool for investigating the role of GSK-3 in diseases such as diabetes, neurodegenerative disorders, and cancer. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and biochemical pathway analysis.

Application

• Biomedical Research: Used as a selective inhibitor to study the physiological and pathological roles of GSK-3 isoforms (α and β) in cellular models.
• Drug Discovery & Development: Serves as a reference compound and a lead structure for developing novel therapeutics targeting GSK-3-related pathways.
• Neurological Disease Research: Applied in studies investigating Alzheimer's disease, Parkinson's disease, and other tauopathies where GSK-3 dysregulation is implicated.
• Metabolic Disorder Studies: Utilized in diabetes and obesity research to understand insulin signaling and glucose metabolism.
• Oncology Research: Employed to explore the involvement of GSK-3 in cell proliferation, apoptosis, and tumor progression.
• Stem Cell Research: Used to modulate Wnt/β-catenin signaling pathways critical for stem cell maintenance and differentiation.

Basic Information

Product Name	Gsk-3 Inhibitor Xv
CAS No.	936112-69-5
Molecular Formula	C₂₀H₂₅N₅O₂
Molecular Weight	367.45 g/mol
Synonyms	GSK-3 Inhibitor XV; 6-[[2-[[4-(2,4-Dichlorophenyl)-5-(4-methyl-1H-imidazol-2-yl)-2-pyrimidinyl]amino]ethyl]amino]-3-pyridinecarbonitrile; CHIR-99021 trihydrochloride (common analog reference); CT99021; GSK-3β Inhibitor XV; Axon 1386; CAS 936112-69-5
EINECS	Contact for details

Quality Control

Our Gsk-3 Inhibitor Xv is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure high batch-to-batch consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a dry environment before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (Mass Spec)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.