Description

Oprozomib CAS NO 935888-69-0 is a potent, orally bioavailable proteasome inhibitor belonging to the class of peptide epoxyketones. This compound is of significant interest for its targeted mechanism of action against the 20S proteasome, a key regulator of intracellular protein degradation. It is primarily utilized by pharmaceutical researchers and developers in the fields of oncology and hematology for the investigation and development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical active pharmaceutical ingredient (API) and reference standard in the preclinical and clinical development of cancer therapeutics.
• Oncology Studies: Used as a biochemical tool to study proteasome inhibition and its effects on cell cycle regulation, apoptosis, and tumor growth in various cancer cell lines.
• Hematological Malignancy Research: Investigated for its potential efficacy in models of multiple myeloma, lymphoma, and leukemia due to its specific mechanism of action.
• Mechanism of Action (MoA) Analysis: Employed in biochemical assays to elucidate the pathways of proteasome-dependent protein degradation and cellular stress response.
• Drug Combination Studies: Utilized in research exploring synergistic effects with other chemotherapeutic agents or targeted therapies.
• Analytical Method Development: Acts as a high-purity standard for developing and validating analytical methods such as HPLC and LC-MS in quality control laboratories.

Basic Information

Product Name	Oprozomib
CAS No.	935888-69-0
Molecular Formula	C₂₅H₃₂N₄O₅
Molecular Weight	468.55 g/mol
Synonyms	ONX 0912; PR-047; (S)-2-((S)-2-(2,5-Difluorophenyl)-1-((S)-2-methyloxiran-2-yl)-2-oxoethylcarbamoyl)-N-((S)-1-((S)-2-methyl-1-(oxetan-3-ylamino)-1-oxopropan-2-ylamino)-1-oxo-3-phenylpropan-2-yl)pyrrolidine-1-carboxamide; Carfilzomib derivative; Epoxyketone proteasome inhibitor
EINECS	Contact for details

Quality Control

Our Oprozomib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling, to ensure it meets the stringent requirements for research and development use. Certificates of Analysis (COA) with detailed chromatographic data (HPLC) are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Unknown Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.