Description

1-[1-(Trifluoroacetyl)Piperidin-4-Yl]Indoline-5-Sulfonyl Chloride is a high-purity, advanced pharmaceutical intermediate characterized by its reactive sulfonyl chloride group and trifluoroacetyl-protected piperidine moiety. This compound matters as a critical building block for medicinal chemists, enabling the efficient synthesis of complex molecules with potential biological activity. It is primarily needed by R&D and production teams in the pharmaceutical and biotechnology industries for developing new active pharmaceutical ingredients (APIs), particularly in areas like kinase inhibitor research.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially for targeted therapies.
• Kinase Inhibitor Development: Used in constructing molecular scaffolds for potential inhibitors of various kinases.
• Chemical Biology & Proteomics: Acts as a reactive handle for labeling or modifying biomolecules in research tools.
• Custom Synthesis & Contract Manufacturing: Serves as a starting material for the production of specialized fine chemicals on a commercial scale.
• Agrochemical Research: Employed in the discovery of new active ingredients with enhanced properties.
• Material Science: Potential use in creating novel polymers or functional materials with specific sulfonamide linkages.

Basic Information

Product Name	1-[1-(Trifluoroacetyl)Piperidin-4-Yl]Indoline-5-Sulfonyl Chloride
CAS No.	935534-42-2
Molecular Formula	C15H14ClF3N2O3S
Molecular Weight	394.79 g/mol
Synonyms	1-[1-(Trifluoroacetyl)-4-piperidinyl]-2,3-dihydro-5-indolinesulfonyl chloride; 5-Indolinesulfonyl chloride, 1-[1-(trifluoroacetyl)-4-piperidinyl]-2,3-dihydro-; 1-(1-(Trifluoroacetyl)piperidin-4-yl)indoline-5-sulfonyl chloride; 935534-42-2; AKOS025147193; 1-[1-(2,2,2-Trifluoroacetyl)piperidin-4-yl]-2,3-dihydro-1H-indole-5-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 1-[1-(Trifluoroacetyl)Piperidin-4-Yl]Indoline-5-Sulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.