Description

2-Bromo-5-Fluoropyridine 1-Oxide is a high-value, multi-functional heterocyclic building block essential for advanced organic synthesis. This compound matters for its unique reactivity profile, offering chemists a versatile handle for constructing complex molecules through cross-coupling and functional group transformations. It is primarily needed by R&D and production teams in the pharmaceutical, agrochemical, and material science industries for developing new active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the fluorine and bromine substituents for bioactivity.
• Material Science Building Block: Employed in the creation of specialized ligands for catalysis and as a monomer or precursor for advanced polymers and electronic materials.
• Cross-Coupling Reactions: Serves as a crucial substrate in Suzuki-Miyaura, Buchwald-Hartwig, and other palladium-catalyzed coupling reactions to form new carbon-carbon and carbon-heteroatom bonds.
• Functional Group Manipulation: The N-oxide and halogen functionalities allow for directed metalation and subsequent introduction of diverse substituents, enabling rapid scaffold diversification.
• Chemical Research & Development: A valuable tool for medicinal and process chemists in lead optimization and route scouting during drug discovery campaigns.

Basic Information

Product Name	2-Bromo-5-Fluoropyridine 1-Oxide
CAS No.	935534-39-7
Molecular Formula	C5H3BrFNO
Molecular Weight	191.99 g/mol
Synonyms	2-Bromo-5-fluoropyridine N-oxide; 5-Fluoro-2-bromopyridine 1-oxide; 2-Bromo-5-fluoropyridine oxide; Pyridine, 2-bromo-5-fluoro-, 1-oxide; 935534-39-7; 2-Br-5-F-Pyridine N-Oxide
EINECS	Contact for details

Quality Control

Our 2-Bromo-5-Fluoropyridine 1-Oxide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.