Description

4-Bromo-3-Fluorobenzenesulfonylfluoride is a high-purity, multi-functional organosulfur and organofluorine building block of significant commercial importance. Its unique molecular structure, featuring both a sulfonyl fluoride and halogenated aromatic ring, makes it a critical intermediate for advanced chemical synthesis. This compound is primarily sought after by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty materials sectors for developing novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, particularly in protease inhibitor and kinase inhibitor research.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides that leverage the sulfonyl fluoride moiety for biological activity.
• Chemical Biology & Proteomics: Serves as a reactive handle in activity-based protein profiling (ABPP) and the development of covalent inhibitors due to the electrophilic sulfonyl fluoride group.
• Polymer & Material Science: Intermediate for synthesizing specialty monomers and polymers, including sulfonated materials for ion-exchange membranes or high-performance resins.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create more complex biaryl structures.
• Ligand & Catalyst Development: Precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	4-Bromo-3-Fluorobenzenesulfonylfluoride
CAS No.	935534-33-1
Molecular Formula	C6H3BrF2O2S
Molecular Weight	256.05 g/mol
Synonyms	4-Bromo-3-fluorobenzenesulfonyl fluoride; 3-Fluoro-4-bromobenzenesulfonyl fluoride; Benzenesulfonyl fluoride, 4-bromo-3-fluoro-; 935534-33-1; 4-Br-3-F-PhSO2F; 1-Bromo-2-fluoro-4-(fluorosulfonyl)benzene
EINECS	Contact for details

Quality Control

Our 4-Bromo-3-Fluorobenzenesulfonylfluoride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and cGMP intermediate synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and reducing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.