Description

Ly 294002 is a potent and selective cell-permeable inhibitor of phosphatidylinositol 3-kinase (PI3K), a key enzyme in cellular signaling pathways. This compound is a critical research tool for studying the role of the PI3K/Akt/mTOR pathway in processes such as cell growth, proliferation, and survival. It is primarily utilized by researchers and scientists in the fields of academic research, pharmaceutical R&D, and biotechnology for investigating cancer biology, metabolic disorders, and neurological diseases.

Application

• Biomedical Research: Fundamental research tool for studying the PI3K/Akt signaling pathway in cell culture and animal models.
• Oncology Studies: Used to investigate tumor cell proliferation, apoptosis, and chemoresistance mechanisms in various cancer types.
• Drug Discovery & Development: Serves as a reference compound and pharmacological probe in high-throughput screening and target validation for new therapeutic agents.
• Metabolic Disorder Research: Applied in studies related to insulin signaling, glucose metabolism, and related pathologies.
• Neuroscience Research: Utilized to explore the role of PI3K in neuronal survival, synaptic plasticity, and neurodegenerative conditions.
• Immunology Research: Investigates the function of PI3K in immune cell activation, differentiation, and inflammatory responses.

Basic Information

Product Name	Ly 294002
CAS No.	934389-88-5
Molecular Formula	C19H17NO5
Molecular Weight	339.34 g/mol
Synonyms	2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; LY-294002; LY294002; 2-(4-Morpholinyl)-8-phenylchromone; PI3K Inhibitor LY294002; 8-Phenyl-2-(morpholin-4-yl)chromen-4-one
EINECS	Contact for details

Quality Control

Our Ly 294002 is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and potency. A Certificate of Analysis (COA) detailing purity, impurities, and analytical results is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.