Description

Nvp-Hsp990 (Hsp990) is a potent and selective small molecule inhibitor of the Heat Shock Protein 90 (Hsp90) family. This compound is of significant interest in pharmaceutical research and development due to its role in modulating client protein stability and function, which is a critical pathway in various disease states. It is primarily utilized by research institutions and pharmaceutical companies engaged in oncology, neurodegenerative disease research, and the development of novel therapeutic agents targeting protein homeostasis.

Application

• Biomedical Research: Used as a critical pharmacological tool to study Hsp90 biology, chaperone function, and related cellular stress response pathways in vitro and in vivo.
• Oncology Drug Discovery: Serves as a lead compound or reference standard in the development of novel anti-cancer therapies targeting Hsp90-dependent oncogenic clients.
• Neurodegenerative Disease Models: Applied in research investigating protein misfolding diseases, such as Alzheimer's and Parkinson's, to understand the role of chaperone systems.
• Mechanistic Studies: Employed to elucidate the downstream effects of Hsp90 inhibition on signal transduction, cell cycle regulation, and apoptosis.
• High-Throughput Screening (HTS): Acts as a control or validation compound in assay development and screening campaigns for Hsp90 inhibitors.
• Preclinical Development: Used in pharmacokinetic, pharmacodynamic, and toxicology studies to support the advancement of candidate molecules.

Basic Information

Product Name	Nvp-Hsp990 (Hsp990)
CAS No.	934343-74-5
Molecular Formula	C₂₃H₂₅ClN₄O₃
Molecular Weight	440.92 g/mol
Synonyms	HSP990; NVP-HSP990; NVP-HSP-990; 5-[2,4-Dihydroxy-5-(1-methylethyl)phenyl]-2,4-dihydro-4-(1-methyl-1H-indol-5-yl)-3H-1,2,4-triazol-3-one; 5-(2,4-Dihydroxy-5-isopropylphenyl)-4-(1-methyl-1H-indol-5-yl)-2,4-dihydro-3H-1,2,4-triazol-3-one; UNII-6Q5U8B5Q6F; 6Q5U8B5Q6F
EINECS	Contact for details

Quality Control

Our Nvp-Hsp990 (Hsp990) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research use. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, typically between 15-25°C, in a dry environment. The product is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.