Description

3-Ethynyl-2-Fluoropyridine is a high-value, multi-functional heterocyclic building block featuring both a fluorine substituent and an ethynyl group. This unique molecular architecture makes it a critical intermediate for the synthesis of complex molecules in advanced research and development. It is primarily sought after by pharmaceutical, agrochemical, and material science industries for applications in medicinal chemistry, ligand synthesis, and the creation of novel polymers.

Application

• Pharmaceutical Intermediate: A key synthon for constructing active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the development of novel herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Ligand & Catalyst Development: The ethynyl group serves as a versatile handle for click chemistry and the construction of complex ligands for catalysis.
• Material Science Precursor: Employed in the synthesis of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Utilized as a tagging moiety or linker in the design of molecular probes and bioconjugates.
• Cross-Coupling Reactions: Acts as a substrate in Sonogashira, Suzuki, and other palladium-catalyzed cross-coupling reactions to build complex molecular frameworks.

Basic Information

Product Name	3-Ethynyl-2-Fluoropyridine
CAS No.	933768-06-0
Molecular Formula	C7H4FN
Molecular Weight	121.11 g/mol
Synonyms	2-Fluoro-3-ethynylpyridine; 3-Ethynyl-2-fluoropyridine; 2-Fluoro-3-pyridylacetylene; 3-Pyridylacetylene, 2-fluoro-; 2-Fluoropyridin-3-ylacetylene
EINECS	Contact for details

Quality Control

Every batch of 3-Ethynyl-2-Fluoropyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up. A detailed Certificate of Analysis (COA), including results from HPLC, NMR, and GC-MS, is supplied with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep the container sealed under an inert atmosphere to prevent degradation. This material is moisture-sensitive (hygroscopic) and should be handled in a dry environment.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.