Description

1-Chloro-3-Trifluoromethanesulfonyl-Benzene is a high-purity, versatile organofluorine building block. This compound is valued for its unique combination of a reactive chlorine substituent and a highly electron-withdrawing trifluoromethanesulfonyl (triflyl) group, making it a critical intermediate in advanced synthesis. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring sulfonamide or sulfone moieties.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the triflyl group enhances biological activity.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: The chlorine atom is amenable to various palladium-catalyzed reactions (e.g., Suzuki, Buchwald-Hartwig) for carbon-carbon and carbon-heteroatom bond formation.
• Ligand and Catalyst Development: Employed in the creation of novel ligands and organocatalysts for asymmetric synthesis.
• Fluorine Chemistry: A valuable substrate for further functionalization via nucleophilic aromatic substitution or metal-halogen exchange.

Basic Information

Product Name	1-Chloro-3-Trifluoromethanesulfonyl-Benzene
CAS No.	933674-85-2
Molecular Formula	C7H4ClF3O2S
Molecular Weight	244.62 g/mol
Synonyms	3-Chlorophenyl trifluoromethanesulfonate; 1-Chloro-3-((trifluoromethyl)sulfonyl)benzene; m-Chlorophenyl triflate; 3-Chlorophenyl triflate; 3-Chlorophenyl trifluoromethylsulfonate; (3-Chlorophenyl) trifluoromethanesulfonate; Trifluoromethanesulfonic acid 3-chlorophenyl ester
EINECS	Contact for details

Quality Control

Our 1-Chloro-3-Trifluoromethanesulfonyl-Benzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing including HPLC, GC, NMR, and IR spectroscopy to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and reducing agents. Recommended storage temperature is 2-8°C for long-term stability. The compound is compatible with strong acid/organic solvent environments but should be handled with standard laboratory precautions.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.