Description

Asapiprant CAS NO 932372-01-5 is a potent and selective prostaglandin D2 (PGD2) receptor antagonist, specifically targeting the CRTH2 (chemoattractant receptor-homologous molecule expressed on Th2 cells) receptor. This compound is of significant interest for its role in modulating inflammatory and allergic pathways mediated by PGD2. It is primarily utilized by pharmaceutical research and development organizations engaged in the discovery of novel therapeutics for conditions such as asthma, allergic rhinitis, and other eosinophil-associated disorders.

Application

• Pharmaceutical Intermediate: Serves as a key active pharmaceutical ingredient (API) or advanced intermediate in the synthesis of investigational anti-inflammatory and anti-allergic drugs.
• Biomedical Research: Used as a selective CRTH2 antagonist in preclinical studies to elucidate the role of the PGD2-CRTH2 axis in immune responses and disease models.
• Drug Discovery & Development: A critical tool compound for high-throughput screening (HTS), target validation, and structure-activity relationship (SAR) studies in immunology and respiratory therapy research.
• Reference Standard: Employed as an analytical standard in quality control laboratories for method development and impurity profiling of related pharmaceutical products.

Basic Information

Product Name	Asapiprant
CAS No.	932372-01-5
Molecular Formula	C₂₀H₂₀F₃N₃O₂
Molecular Weight	391.39 g/mol
Synonyms	ASP-015K; JNJ-3871; JNJ-3871078; 2-[4-(1,3-Benzothiazol-2-ylsulfanyl)phenyl]-1-(3,5-dichloropyridin-4-yl)ethanone; (R)-2-[4-(Benzothiazol-2-ylsulfanyl)phenyl]-1-(3,5-dichloropyridin-4-yl)ethanone; CRTH2 antagonist JNJ-3871
EINECS	Contact for details

Quality Control

Our Asapiprant is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. We provide full traceability and Certificates of Analysis (COA) are available upon request, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.