Description

Tranilast is a synthetic derivative of N-(3,4-dimethoxycinnamoyl) anthranilic acid, functioning as a potent anti-allergic and anti-fibrotic agent. Its primary value lies in its ability to inhibit the release of chemical mediators from mast cells and suppress the proliferation and collagen synthesis of fibroblasts. This makes it a critical intermediate and active pharmaceutical ingredient (API) for manufacturers targeting inflammatory and fibrotic disorders. Key industries requiring this compound include the pharmaceutical sector for drug development and the fine chemical industry for advanced research.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of anti-allergic and anti-asthmatic medications.
• Key intermediate in the research and development of novel therapeutics for fibrotic diseases, including keloids, hypertrophic scars, and systemic sclerosis.
• Utilized in clinical studies investigating treatments for conditions like bronchial asthma, atopic dermatitis, and allergic conjunctivitis.
• Employed as a reference standard in analytical laboratories for quality control and method validation (HPLC, LC-MS).
• Serves as a building block in organic synthesis for creating new chemical entities with modified biological activity.
• Used in biochemical research to study mast cell stabilization and TGF-β (Transforming Growth Factor-beta) signaling pathways.

Basic Information

Product Name	Tranilast
CAS No.	53902-12-8
Molecular Formula	C18H17NO5
Molecular Weight	327.33 g/mol
Synonyms	N-(3,4-Dimethoxycinnamoyl)anthranilic Acid; Rizaben; N-5'; Tranilastum; N-(3',4'-Dimethoxycinnamoyl)anthranilic Acid; 2-[[(2E)-3-(3,4-Dimethoxyphenyl)prop-2-enoyl]amino]benzoic Acid; Tranilast (USAN); MK-341
EINECS	258-904-7

Quality Control

Our Tranilast is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. The product is tested against rigorous in-house specifications, which typically include identification, assay, and impurity profile analysis. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment. We can support development and commercial projects requiring material that aligns with ICH guidelines and current Good Manufacturing Practice (cGMP) principles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.