Description

Tranilast (Sodium) is the sodium salt form of Tranilast, a synthetic derivative of N-(3,4-dimethoxycinnamoyl) anthranilic acid. This compound is valued for its potent anti-allergic and anti-fibrotic properties, acting as a mast cell stabilizer and inhibitor of cytokine release. It is a critical active pharmaceutical ingredient (API) and research chemical for developers in the pharmaceutical and life science sectors. The product is supplied under the identifier CAS NO 104931-56-8.

Application

• Pharmaceutical API: Primary use as the active ingredient in formulations for treating allergic disorders such as bronchial asthma, allergic rhinitis, and atopic dermatitis.
• Anti-fibrotic Research: Key compound in preclinical and clinical research targeting fibrotic diseases, including keloids, hypertrophic scars, and systemic sclerosis.
• Mast Cell Stabilizer: Used in studies investigating the inhibition of mast cell degranulation and the subsequent release of histamine and other inflammatory mediators.
• Ophthalmic Preparations: Investigated for use in eye drops to manage allergic conjunctivitis and other inflammatory ocular conditions.
• Intermediate for Derivatives: Serves as a crucial synthetic intermediate for the preparation of other tranilast analogs and prodrugs.
• Reference Standard: Utilized as a high-purity analytical reference standard in quality control laboratories for HPLC, LC-MS, and NMR.

Basic Information

Item	Detail
Product Name	Tranilast (Sodium)
CAS No.	104931-56-8
Molecular Formula	C18H15NNaO5
Molecular Weight	348.31 g/mol
Synonyms	Tranilast Sodium Salt; Sodium Tranilate; N-(3,4-Dimethoxycinnamoyl)anthranilic Acid Sodium Salt; Tranilast Na; Rizaben (brand name reference); KCA-757; Tranilast Sodium Hydrate; 2-[[3-(3,4-Dimethoxyphenyl)-1-oxo-2-propen-1-yl]amino]benzoic Acid Sodium Salt
EINECS	Contact for details

Quality Control

Our Tranilast (Sodium) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency, meeting specifications suitable for pharmaceutical research and development. A Certificate of Analysis (COA) detailing results for assay, related substances, residual solvents, and other critical parameters is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.