Description

Ticolubant CAS NO 154413-61-3 is a potent and selective antagonist of the cysteinyl leukotriene receptor 1 (CysLT1). This compound is a critical research tool for investigating inflammatory pathways, particularly those involved in asthma and allergic responses. It is essential for pharmaceutical R&D, academic research, and the development of novel therapeutic agents targeting leukotriene-mediated conditions.

Application

• Pharmaceutical Research & Development: A key reference standard and active pharmaceutical ingredient (API) intermediate in the development of anti-asthma and anti-allergy medications.
• Biochemical Assay Development: Used as a selective CysLT1 receptor antagonist to validate assay systems and study receptor-ligand interactions in vitro.
• Mechanism of Action Studies: Employed in preclinical research to elucidate the role of cysteinyl leukotrienes in inflammatory diseases, including bronchoconstriction and vascular permeability.
• Academic & Institutional Research: Serves as a vital compound for universities and research institutes studying pulmonary pharmacology and immunology.
• Drug Discovery Screening: Utilized in high-throughput screening (HTS) campaigns to identify and characterize new compounds targeting the leukotriene pathway.

Basic Information

Product Name	Ticolubant
CAS No.	154413-61-3
Molecular Formula	C23H23ClN2O3S
Molecular Weight	442.96 g/mol
Synonyms	ICI 198615; ICI-198615; RG 12525; RG-12525; 4-[[4-[[1-[[(4-Chlorophenyl)amino]carbonyl]-2-(2-furanylmethyl)-1H-benzimidazol-5-yl]oxy]butyl]thio]benzoic Acid; CysLT1 Antagonist
EINECS	Contact for details

Quality Control

Our Ticolubant is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.