Description

4-(8-Chloro-6,11-Dihydro-11-Hydroxy-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridin-11-Yl)-1-Piperidinecarboxylic Acid Ethyl Ester is a high-purity pharmaceutical intermediate with a complex heterocyclic structure. This compound is critical for the synthesis of advanced active pharmaceutical ingredients (APIs), particularly in the development of novel therapeutic agents. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and contract research organizations (CROs) engaged in the development of new chemical entities.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Active Pharmaceutical Ingredient (API) Synthesis: Serves as a precursor in multi-step synthetic routes for complex target molecules.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes.
• Contract Manufacturing (CMO): Supplied to contract manufacturing organizations for scale-up and GMP production of clinical trial materials.
• Reference Standard: Sourced for analytical method development, validation, and quality control as a high-purity reference compound.
• Academic Research: Utilized in university and institutional labs for advanced organic synthesis and pharmacological studies.

Basic Information

Product Name	4-(8-Chloro-6,11-Dihydro-11-Hydroxy-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridin-11-Yl)-1-Piperidinecarboxylic Acid Ethyl Ester
CAS No.	133284-74-9
Molecular Formula	C22H23ClN2O3
Molecular Weight	398.88 g/mol
Synonyms	Ethyl 4-(8-chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperidine-1-carboxylate; 4-(8-Chloro-11-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic acid ethyl ester; Loratadine Related Compound; Loratadine Intermediate; Desloratadine Synthesis Intermediate; 133284-74-9; 4-(8-Chloro-6,11-dihydro-11-hydroxy-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)-1-piperidinecarboxylic acid, ethyl ester
EINECS	Contact for details

Quality Control

Our 4-(8-Chloro-6,11-Dihydro-11-Hydroxy-5H-Benzo[5,6]Cyclohepta[1,2-B]Pyridin-11-Yl)-1-Piperidinecarboxylic Acid Ethyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to meet specific client requirements or pharmacopeial standards (e.g., USP, EP).

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed and stored in a dark environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.