Description

Setipafant is a potent and selective antagonist of the platelet-activating factor (PAF) receptor, identified by CAS NO 132418-35-0. This compound is a critical research tool for investigating inflammatory pathways and has been studied for its potential therapeutic applications. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and contract research organizations (CROs) focused on immunology, respiratory diseases, and inflammatory disorders.

Application

• Pharmacological Research: A key reference standard and tool compound for studying the role of PAF in inflammatory and allergic responses.
• Drug Discovery & Development: Used in preclinical studies to validate PAF receptor as a target for new anti-inflammatory or anti-asthma therapeutics.
• Biochemical Assays: Employed in in vitro binding assays and functional cellular tests to characterize receptor antagonism and signal transduction.
• Academic Research: Supports fundamental research in immunology, pulmonology, and cardiovascular physiology related to PAF-mediated processes.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in analytical laboratories.

Basic Information

Product Name	Setipafant
CAS No.	132418-35-0
Molecular Formula	C24H28N4O4S
Molecular Weight	468.57 g/mol
Synonyms	WEB 2170; BS 2170; 4-(2-Chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)propyl]-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine; 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine, 4-(2-chlorophenyl)-9-methyl-2-[3-(4-morpholinyl)propyl]-; PAF Receptor Antagonist WEB 2170
EINECS	Contact for details

Quality Control

Our Setipafant is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant standards for research chemicals, and specifications can be aligned with client requirements for advanced pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.