Description

Acitazanolast is a selective and potent inhibitor of 5-lipoxygenase (5-LO), a key enzyme in the leukotriene biosynthesis pathway. This targeted mechanism of action makes it a valuable research tool for investigating inflammatory and allergic responses at the molecular level. It is primarily utilized by pharmaceutical R&D teams and academic researchers focused on developing novel therapeutics for conditions such as asthma, allergic rhinitis, and other leukotriene-mediated disorders.

Application

• Pharmaceutical Research & Development: A critical reference standard and biochemical tool for studying the 5-lipoxygenase pathway and screening potential anti-inflammatory drug candidates.
• Inflammation & Immunology Studies: Used in in vitro and in vivo models to elucidate the role of leukotrienes in various inflammatory diseases.
• Allergy Research: Employed to investigate mechanisms underlying allergic reactions and to evaluate the efficacy of new anti-allergic agents.
• Biochemical Assay Development: Serves as a potent control inhibitor in enzymatic assays designed to measure 5-LO activity.
• Academic Research: Used in university and institutional labs for fundamental research into eicosanoid biology and signal transduction.
• Preclinical Development: Supports pharmacokinetic and pharmacodynamic studies for novel compounds targeting the arachidonic acid cascade.

Basic Information

Product Name	Acitazanolast
CAS No.	114607-46-4
Molecular Formula	C20H17N3O4S
Molecular Weight	395.43 g/mol
Synonyms	FR-110302; Acitazanolastum; 4-(3,4-Dimethoxyphenyl)-2-[2-(1H-tetrazol-5-yl)ethyl]thiazole; 2-[2-(1H-Tetrazol-5-yl)ethyl]-4-(3,4-dimethoxyphenyl)thiazole; 5-[2-[4-(3,4-Dimethoxyphenyl)-1,3-thiazol-2-yl]ethyl]-1H-tetrazole
EINECS	Contact for details

Quality Control

Our Acitazanolast is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, IR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and performance.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.