Description

8-Bromoquinoline-5-Sulfonyl Chloride is a high-purity, multi-functional organic intermediate primarily used in advanced chemical synthesis. This compound is valued for its reactive sulfonyl chloride group and halogenated quinoline core, which enable its use as a key building block for creating complex molecules. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and material science industries developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel drug candidates, particularly in the development of kinase inhibitors and other biologically active heterocyclic compounds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the quinoline scaffold contributes to biological activity.
• Material Science Research: Acts as a monomer or functionalization agent in the creation of specialty polymers, organic semiconductors, and metal-organic frameworks (MOFs).
• Dye and Pigment Manufacturing: Employed in the synthesis of complex quinoline-based dyes and fluorescent markers for analytical and industrial applications.
• Chemical Biology Probes: Utilized to create sulfonamide-based probes and labeling reagents for protein studies and diagnostic assay development.
• Cross-Coupling Reactions: The bromine substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) to construct more elaborate molecular architectures.

Basic Information

Product Name	8-Bromoquinoline-5-Sulfonyl Chloride
CAS No.	930396-14-8
Molecular Formula	C9H5BrClNO2S
Molecular Weight	306.56 g/mol
Synonyms	8-Bromo-5-quinolinesulfonyl chloride; Quinoline-5-sulfonyl chloride, 8-bromo-; 8-Bromoquinoline-5-sulfonylchloride; 5-Quinolinesulfonyl chloride, 8-bromo-; 930396-14-8; 8-Br-5-QSC; 8-Bromo-quinoline-5-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 8-Bromoquinoline-5-Sulfonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.