Description

1-Bromo-2-Methyl-4-(Trifluoromethyl)Benzene, also known as 2-Bromo-5-Trifluoromethyltoluene, is a high-value halogenated aromatic building block. This compound is prized for its unique trifluoromethyl and bromine substituents, which are critical for modulating the lipophilicity, metabolic stability, and binding affinity of target molecules. It is an essential intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the synthesis of active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the synthesis of fluorinated organic compounds for electronic displays and optoelectronic devices.
• Functional Material Development: Employed in creating specialty polymers, ligands for catalysis, and advanced organic frameworks with tailored properties.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form complex biaryl structures.
• Chemical Research & Development: A versatile reagent for academic and industrial R&D in organic and medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Item	Detail
Product Name	1-Bromo-2-Methyl-4-(Trifluoromethyl)Benzene, 2-Bromo-5-Trifluoromethyltoluene
CAS No.	929000-62-4
Molecular Formula	C8H6BrF3
Molecular Weight	239.04 g/mol
Synonyms	2-Bromo-5-(trifluoromethyl)toluene; 2-Bromo-α,α,α-trifluoro-p-xylene; 1-Bromo-2-methyl-4-(trifluoromethyl)benzene; 5-Trifluoromethyl-2-bromotoluene; 2-Methyl-5-trifluoromethylphenyl bromide; 4-Bromo-3-methylbenzotrifluoride; α,α,α-Trifluoro-2-bromo-5-methyltoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Methyl-4-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment supports compliance with cGMP and ISO standards for reliable integration into your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and bases. Recommended storage temperature is 2-8°C for long-term stability. Keep container tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.