Description

15-Lipoxygenase Inhibitor 1 is a potent and selective small-molecule inhibitor of the 15-lipoxygenase (15-LOX) enzyme, a key mediator in the biosynthesis of pro-inflammatory lipid mediators. This compound is crucial for researchers and developers targeting inflammatory pathways, offering a valuable tool for elucidating the role of 15-LOX in disease models and therapeutic development. It is primarily utilized in pharmaceutical R&D for the investigation of conditions such as atherosclerosis, asthma, and certain cancers, where 15-LOX activity is implicated.

Application

• Pharmaceutical Research & Development: As a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel anti-inflammatory therapeutics.
• Biochemical Assay Development: Used as a selective inhibitor in enzymatic assays to study 15-LOX activity, substrate specificity, and inhibitor screening.
• Inflammation & Immunology Studies: A key tool compound for in vitro and in vivo research into the role of the 15-LOX pathway in chronic inflammatory diseases.
• Cardiovascular Disease Research: Investigated for its potential effects on atherosclerosis and plaque stability through modulation of lipid oxidation processes.
• Oncology Research: Employed in studies exploring the connection between lipoxygenase pathways, oxidative stress, and cancer cell proliferation.
• Academic & Contract Research: Supplied to universities and CROs for fundamental biological research and preclinical testing.

Basic Information

Product Name	15-Lipoxygenase Inhibitor 1
CAS No.	928853-86-5
Molecular Formula	C23H21N3O3S
Molecular Weight	419.50 g/mol
Synonyms	15-LOX Inhibitor 1; 2-[(4-Methoxyphenyl)methyl]-3-[(4-methylphenyl)sulfonyl]-1H-indole-5-carbonitrile; MLS000518935; 1H-Indole-5-carbonitrile, 2-[(4-methoxyphenyl)methyl]-3-[(4-methylphenyl)sulfonyl]-; CID 46897832; 15-Lipoxygenase-1 Inhibitor; 15-LO-1 Inhibitor
EINECS	Contact for details

Quality Control

Every batch of 15-Lipoxygenase Inhibitor 1 is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and support regulatory submissions with detailed documentation. A Certificate of Analysis (COA) is supplied with each shipment, detailing results for assay, purity (HPLC), and related substances.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. The compound is light-sensitive; prolonged exposure to light should be avoided to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.