Description

2-Fluoro-3-Iodo-5-Phenylpyridine is a high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique structure, featuring fluorine and iodine substituents on the pyridine ring, makes it an essential intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for drug discovery and the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging its halogenated structure for bioactivity.
• Material Science: Serves as a monomer or functionalization agent in the creation of specialty polymers and organic electronic materials.
• Cross-Coupling Reactions: The iodine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Sonogashira) to form carbon-carbon bonds.
• Ligand Synthesis: Utilized for the preparation of novel nitrogen-containing ligands for catalysis and coordination chemistry.
• Chemical Biology: Employed as a probe or tag in medicinal chemistry for structure-activity relationship (SAR) studies.

Basic Information

Product Name	2-Fluoro-3-Iodo-5-Phenylpyridine
CAS No.	928822-81-5
Molecular Formula	C11H7FIN
Molecular Weight	299.08 g/mol
Synonyms	3-Iodo-2-fluoro-5-phenylpyridine; 5-Phenyl-2-fluoro-3-iodopyridine; 2-Fluoro-3-iodo-5-phenylpyridine; 928822-81-5; 2-Fluoro-3-iodo-5-phenyl-pyridine; Pyridine, 2-fluoro-3-iodo-5-phenyl-; 5-Phenyl-3-iodo-2-fluoropyridine
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Iodo-5-Phenylpyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our quality commitment supports applications requiring high-purity intermediates under cGMP or ISO 9001 frameworks.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.