Description

Bibf-1120 is a potent and selective small molecule inhibitor targeting receptor tyrosine kinases, primarily developed for research and pharmaceutical applications. This compound is of significant interest for its potential in modulating key signaling pathways involved in cell proliferation and angiogenesis. It is primarily utilized by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in oncology and fibrosis research. The material is supplied as a high-purity reference standard to support drug discovery and development efforts.

Application

• Pharmaceutical Research & Development: Serves as a critical reference standard and active pharmaceutical ingredient (API) intermediate in the development of novel kinase inhibitor therapies.
• Oncology Research: Used in in vitro and in vivo studies to investigate its efficacy against various cancer cell lines and tumor models.
• Biochemical Assays: Employed as a selective inhibitor in high-throughput screening (HTS) and enzymatic assays to study kinase activity and signaling pathways.
• Preclinical Studies: Essential for pharmacokinetics (PK), pharmacodynamics (PD), and toxicology evaluations during the drug discovery pipeline.
• Academic Research: Supports fundamental research in cell biology, signal transduction, and the mechanisms of angiogenesis and fibrosis.
• Chemical Synthesis: Acts as a key building block or intermediate for the synthesis of more complex derivatives and analogs.

Basic Information

Product Name	Bibf-1120
CAS No.	928326-83-4
Molecular Formula	C₃₁H₄₁N₇O₄
Molecular Weight	575.71 g/mol
Synonyms	Nintedanib (BIBF 1120); BIBF-1120; BIBF 1120; 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester; Vargatef; OFEV; Intedanib; Methyl (3Z)-3-{[4-(N-methyl-2-{[4-(methylcarbamoyl)piperazin-1-yl]acetamido}anilino)phenyl]methylidene}-2-oxo-2,3-dihydro-1H-indole-6-carboxylate
EINECS	Contact for details

Quality Control

Our Bibf-1120 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) documenting identity, purity, and all relevant specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.