Description

Selonsertib is a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1), a key mediator of cellular stress and inflammation pathways. This compound is a critical research tool and pharmaceutical intermediate for developing novel therapeutics targeting fibrotic, inflammatory, and metabolic diseases. It is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions engaged in drug discovery programs for non-alcoholic steatohepatitis (NASH), chronic kidney disease, and other conditions driven by oxidative stress.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of investigational new drugs targeting ASK1.
• Biomedical Research: Used as a reference standard and active probe in in vitro and in vivo studies to elucidate the role of ASK1 in disease pathology.
• Drug Discovery & Development: A vital compound for high-throughput screening, lead optimization, and preclinical efficacy testing in fibrosis and inflammation models.
• Mechanistic Studies: Enables research into stress-activated signaling cascades involving p38 MAPK and JNK pathways.
• Reference Material: Serves as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.

Basic Information

Product Name	Selonsertib
CAS No.	1448428-04-3
Molecular Formula	C₂₀H₁₅F₂N₅O₂
Molecular Weight	395.36 g/mol
Synonyms	GS-4997; 6-[5-[(2,4-Difluorophenyl)methoxy]-1H-pyrazolo[3,4-c]pyridin-3-yl]-3-(2-methyl-2-propanyl)-3H-imidazo[4,5-b]pyridine; ASK1 Inhibitor; Apoptosis Signal-regulating Kinase 1 Inhibitor; 6-(5-((2,4-Difluorobenzyl)oxy)-1H-pyrazolo[3,4-c]pyridin-3-yl)-3-(tert-butyl)-1H-imidazo[4,5-b]pyridine
EINECS	Contact for details

Quality Control

Our Selonsertib is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Heavy Metals	<10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.