Description

Selonsertib Hcl Salt, Gs-4997 Hcl Salt CAS NO 1448428-05-4 is the hydrochloride salt form of Selonsertib, a potent and selective inhibitor of apoptosis signal-regulating kinase 1 (ASK1). This high-purity active pharmaceutical ingredient (API) is critical for pharmaceutical research and development, particularly in targeting pathways associated with inflammation, fibrosis, and apoptosis. It is primarily required by pharmaceutical companies, biotechnology research firms, and academic institutions engaged in the development of novel therapeutics for conditions such as nonalcoholic steatohepatitis (NASH), liver fibrosis, and other inflammatory diseases.

Application

• Pharmaceutical R&D: Core material for preclinical and clinical research into ASK1-mediated diseases.
• Reference Standard: Used as a certified reference material (CRM) for analytical method development and validation in quality control laboratories.
• Drug Formulation Studies: Serves as the active ingredient in formulation development for solid dosage forms like tablets and capsules.
• Biochemical Research: A key tool for studying the JNK and p38 MAPK signaling pathways in cellular models of stress and inflammation.
• Process Chemistry: Used in scaling up synthetic routes and optimizing manufacturing processes for GMP production.

Basic Information

Product Name	Selonsertib Hcl Salt, Gs-4997 Hcl Salt
CAS No.	1448428-05-4
Molecular Formula	C₂₀H₁₉ClN₄O₃ • HCl
Molecular Weight	427.75 g/mol (for the salt form)
Synonyms	GS-4997 Hydrochloride; Selonsertib Hydrochloride; 6-[5-[(2,4-Difluorophenyl)thio]-4-(4-morpholinyl)-2-pyrimidinyl]-1-methyl-1H-indole hydrochloride; ASK1 Inhibitor; Gilead Sciences-4997 HCl; GS4997 HCl; UNII-4F8VJ29K8H
EINECS	Contact for details

Quality Control

Our Selonsertib HCl Salt is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and assay, identification by spectroscopic methods (IR, NMR), and stringent control of impurities (related substances, residual solvents, heavy metals). We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with relevant guidelines for pharmaceutical intermediates and APIs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency. For long-term storage, consider desiccants and a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤1.0%
Related Substances (HPLC)	Total impurities ≤2.0%; Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.