Description

Nintedanib CAS NO 656247-17-5 is a potent, orally active triple angiokinase inhibitor targeting key receptor tyrosine kinases involved in pathological tissue remodeling. This high-purity active pharmaceutical ingredient (API) is critical for the development and manufacturing of innovative therapeutics targeting fibrotic diseases. It is primarily required by pharmaceutical companies and research institutions engaged in the formulation of treatments for idiopathic pulmonary fibrosis (IPF) and other interstitial lung diseases.

Application

• Pharmaceutical API: Primary active ingredient in the commercial production of anti-fibrotic medications.
• Oncology Research: Investigation into its efficacy against various cancers due to its anti-angiogenic properties.
• Pulmonary Fibrosis Treatment: Formulation development for drugs targeting IPF and other progressive fibrosing interstitial lung diseases.
• Preclinical & Clinical Studies: Use in non-clinical safety assessments and clinical trial material (CTM) manufacturing.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in laboratories.
• Drug Discovery: A key compound for structure-activity relationship (SAR) studies in kinase inhibitor research.

Basic Information

Product Name	Nintedanib
CAS No.	656247-17-5
Molecular Formula	C31H33N5O4
Molecular Weight	539.62 g/mol
Synonyms	BIBF 1120; Intedanib; Vargatef; Nintedanib esylate; 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester; BIBF-1120; OFEV (brand name formulation)
EINECS	Contact for details

Quality Control

Our Nintedanib is manufactured under strict quality management systems to ensure it meets the rigorous standards required for pharmaceutical use. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced techniques like HPLC and LC-MS. A Certificate of Analysis (COA) documenting full compliance with specifications is provided with every shipment. We support development and commercial projects requiring adherence to cGMP, ICH Q7, and other relevant regulatory guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under inert conditions or in a desiccator to maintain stability and potency.

Specification

Item	Specification
Appearance	Yellow to brownish powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.5%
Related Substances (HPLC)	Total impurities ≤ 1.5% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.