Description

Bardoxolone is a potent synthetic triterpenoid and a well-characterized activator of the Nrf2 (Nuclear factor erythroid 2-related factor 2) signaling pathway. This compound is of significant interest in pharmaceutical research for its potential to modulate oxidative stress and inflammatory responses. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors for preclinical and clinical-stage investigations into therapeutic applications.

Application

• Pharmaceutical Research & Development: A key investigational agent for studying the Nrf2-Keap1 pathway and its role in cellular defense mechanisms.
• Preclinical Studies: Used in animal models to evaluate efficacy in conditions associated with oxidative stress and chronic inflammation.
• Clinical Trial Material: Serves as an active pharmaceutical ingredient (API) in the manufacture of formulations for human clinical trials.
• Mechanistic Biology: A critical tool compound for elucidating the molecular mechanisms underlying cytoprotective gene expression.
• Therapeutic Area Exploration: Investigated for potential applications in renal diseases, pulmonary conditions, metabolic disorders, and oncology.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Bardoxolone
CAS No.	218600-44-3
Molecular Formula	C31H38O4
Molecular Weight	474.63 g/mol
Synonyms	Bardoxolone; CDDO; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid; RTA 402; NSC 713200; TP-235; 1-[2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oyl]imidazole; CDDO-Im
EINECS	Contact for details

Quality Control

Our Bardoxolone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis to ensure it meets stringent standards for research and development use. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	<20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.