Description

Nintedanib CAS NO 1174335-83-1 is a small molecule tyrosine kinase inhibitor (TKI) with potent activity against multiple receptor tyrosine kinases. This compound is of significant commercial and therapeutic importance as an active pharmaceutical ingredient (API) for the treatment of specific interstitial lung diseases and certain cancers. It is primarily required by pharmaceutical manufacturers, research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the development and production of innovative therapeutics.

Application

• Primary use as an Active Pharmaceutical Ingredient (API) in the formulation of prescription medications.
• Key therapeutic application in the treatment of idiopathic pulmonary fibrosis (IPF) and other progressive fibrosing interstitial lung diseases.
• Use in oncology for the treatment of non-small cell lung cancer (NSCLC) of adenocarcinoma tumor histology.
• Critical raw material for pharmaceutical research and development (R&D) of novel kinase inhibitors.
• Reference standard in analytical laboratories for quality control and method development.
• Intermediate in the synthesis of deuterated or other modified analogs for advanced clinical studies.

Basic Information

Product Name	Nintedanib
CAS No.	1174335-83-1
Molecular Formula	C31H33N5O4
Molecular Weight	539.63 g/mol
Synonyms	Nintedanib esylate; BIBF 1120; Vargatef; Intedanib; 1H-Indole-6-carboxylic acid, 2,3-dihydro-3-[[[4-[methyl[(4-methyl-1-piperazinyl)acetyl]amino]phenyl]amino]phenylmethylene]-2-oxo-, methyl ester; Methyl (3Z)-3-[[4-[methyl(2-(4-methylpiperazin-1-yl)acetyl)amino]phenyl]amino]-3-(2-oxo-2,3-dihydro-1H-indol-6-yl)prop-2-enoate
EINECS	Contact for details

Quality Control

Our Nintedanib is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure it meets high-purity standards suitable for pharmaceutical applications. Certificates of Analysis (COA) are provided, detailing comprehensive results for identity, purity, and impurities. We adhere to cGMP (current Good Manufacturing Practice) guidelines to ensure consistency and traceability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	Yellow to brownish powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single unknown impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.