Description

Fulacimstat (Bay 1142524) is a potent and selective small molecule inhibitor of the enzyme dipeptidyl peptidase 1 (DPP1), also known as cathepsin C. This compound is of significant interest for its role in modulating neutrophil serine protease activity, which is implicated in inflammatory processes. It is primarily utilized by pharmaceutical researchers and developers in the fields of inflammation, immunology, and respiratory diseases for preclinical and clinical-stage investigations.

Application

• Pharmaceutical Research & Development: As a key reference standard and active pharmaceutical ingredient (API) in the development of novel therapeutics for inflammatory conditions.
• Preclinical Studies: For investigating the role of DPP1/cathepsin C in disease models, particularly those involving neutrophil-driven inflammation.
• Mechanism of Action (MoA) Studies: Used to validate DPP1 as a therapeutic target and to study downstream effects on protease activation.
• Respiratory Disease Research: Potential application in research for chronic obstructive pulmonary disease (COPD), bronchiectasis, and α-1 antitrypsin deficiency.
• Biochemical Assay Development: Serves as a critical control compound in high-throughput screening and enzymatic assays targeting DPP1.

Basic Information

Product Name	Fulacimstat (Bay 1142524)
CAS No.	1488354-15-9
Molecular Formula	C₂₀H₂₀F₃N₅O₃
Molecular Weight	435.40 g/mol
Synonyms	BAY 1142524; BAY-1142524; Fulacimstat; (2S)-2-({[1-(2,2-Difluoroethyl)-3-methyl-1H-pyrazol-5-yl]carbonyl}amino)-N-[(3R)-1-(2,2,2-trifluoroethyl)piperidin-3-yl]-5-(trifluoromethyl)benzamide; DPP1 Inhibitor; Cathepsin C Inhibitor
EINECS	Contact for details

Quality Control

Our Fulacimstat (Bay 1142524) is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.