Description

6-Chloro-5-(Trifluoromethyl)Pyridine-3-Sulfonyl Chloride is a high-value, multi-functional chemical intermediate prized for its reactive sulfonyl chloride and halogenated pyridine moieties. Its core value proposition lies in enabling the efficient synthesis of complex sulfonamide derivatives, which are critical scaffolds in modern pharmaceutical and agrochemical discovery. This compound is essential for R&D chemists and process development scientists in the life sciences sector, particularly those developing novel active ingredients with enhanced biological activity and patentability.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of sulfonamide-based drug candidates, including kinase inhibitors, receptor antagonists, and antiviral agents.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the trifluoromethylpyridine core contributes to improved lipophilicity and metabolic stability.
• Material Science Research: Serves as a precursor for functionalized polymers and ligands used in catalysis and advanced materials.
• Custom Synthesis & Contract Manufacturing: Employed by CDMOs for the production of bespoke intermediates for client-specific discovery and development programs.

Basic Information

Product Name	6-Chloro-5-(Trifluoromethyl)Pyridine-3-Sulfonyl Chloride
CAS No.	928324-59-8
Molecular Formula	C7H2Cl2F3NO2S
Molecular Weight	304.06 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 6-chloro-5-(trifluoromethyl)-; 6-Chloro-5-trifluoromethylpyridine-3-sulfonyl chloride; 2-Chloro-3-(chlorosulfonyl)-5-(trifluoromethyl)pyridine; 928324-59-8; 6-Chloro-5-(trifluoromethyl)pyridine-3-sulfonylchloride
EINECS	Contact for details

Quality Control

Our production of 6-Chloro-5-(Trifluoromethyl)Pyridine-3-Sulfonyl Chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and reliability for critical synthetic applications. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.