Description

1-Ethynyl-2-Fluoro-4-Methyl-Benzene is a specialized aromatic building block featuring both an ethynyl and a fluorine substituent on a methylated benzene ring. This unique molecular architecture makes it a valuable intermediate for constructing complex molecules in advanced research and development. It is primarily sought after by pharmaceutical and agrochemical R&D teams for applications in medicinal chemistry and material science. The compound's structure offers versatile reactivity for cross-coupling reactions and the introduction of fluorinated motifs.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic systems.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides where the fluorine atom can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira, Heck, and other palladium-catalyzed coupling reactions to build complex molecular frameworks.
• Fluorine Chemistry Studies: Employed in academic and industrial research to study the effects of fluorine substitution on aromatic systems and reaction pathways.
• Ligand and Catalyst Development: Used to synthesize novel ligands for catalysis or as a structural component in organometallic complexes.

Basic Information

Product Name	1-Ethynyl-2-Fluoro-4-Methyl-Benzene
CAS No.	928304-42-1
Molecular Formula	C9H7F
Molecular Weight	134.15 g/mol
Synonyms	2-Fluoro-4-methylphenylacetylene; 1-Ethynyl-2-fluoro-4-methylbenzene; 2-Fluoro-4-methyl-1-ethynylbenzene; 4-Methyl-2-fluorophenylacetylene; (2-Fluoro-4-methylphenyl)ethyne; 1-Fluoro-2-ethynyl-5-methylbenzene; 2-Fluoro-4-methylbenzenecarbaldehyde
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards for research and industrial use. Each batch is analyzed using advanced techniques including GC, HPLC, and NMR to verify identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications and test results are available upon request. We adhere to a strict quality management system to guarantee reliable and reproducible performance in your synthetic applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flames. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.