Description

(3-Pyridylmethyl)Sulfonyl Chloride Triflate is a specialized organosulfur reagent featuring a reactive sulfonyl chloride group activated by a trifluoromethanesulfonate (triflate) moiety. This compound is valued for its high electrophilicity, making it a critical intermediate for introducing the (3-pyridylmethyl)sulfonyl functional group into target molecules. It is primarily sought by researchers and process chemists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, including the synthesis of sulfonamide-based drug candidates and other bioactive compounds.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel sulfonamide drugs targeting various therapeutic areas.
• Medicinal Chemistry Research: Used in lead optimization and structure-activity relationship (SAR) studies to introduce specific sulfonyl functionalities.
• Agrochemical Synthesis: Intermediate in the production of advanced crop protection agents and herbicides.
• Chemical Biology Probes: Enables the labeling or modification of biomolecules for proteomics and biochemical research.
• Material Science: Potential monomer or cross-linking agent for creating specialized polymers with pyridine and sulfone groups.
• Custom Synthesis: Serves as a starting material for contract research organizations (CROs) and CDMOs for client-specific molecule development.

Basic Information

Product Name	(3-Pyridylmethyl)Sulfonyl Chloride Triflate
CAS No.	928140-28-7
Molecular Formula	C7H6ClF3NO4S2
Molecular Weight	319.70 g/mol
Synonyms	3-(Chlorosulfonylmethyl)pyridine Trifluoromethanesulfonate; 3-Pyridinemethanesulfonyl Chloride Triflate; (Pyridin-3-ylmethyl)sulfonyl Chloride Triflate; 3-(Chlorosulfonylmethyl)pyridinium Triflate; 928140-28-7; (3-Pyridyl)methanesulfonyl chloride triflate; 3-Pyridylmethanesulfonyl Chloride Trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Every batch of (3-Pyridylmethyl)Sulfonyl Chloride Triflate is manufactured and tested under strict quality management protocols to ensure consistency and reliability for research and development. We provide comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry confirmation. A detailed Certificate of Analysis (COA) is available for each lot upon request, supporting your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.