Description

6-Cyanopyridine-3-Sulfonyl Chloride is a versatile and reactive heterocyclic building block essential for advanced organic synthesis. Its bifunctional nature, featuring both a sulfonyl chloride and a nitrile group, makes it a critical intermediate for constructing complex molecules with high precision. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of sulfonamide-based drug candidates, including enzyme inhibitors and receptor modulators.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides that require the sulfonyl moiety for biological activity.
• Material Science: Serves as a precursor for functional polymers, dyes, and liquid crystals where the pyridine-sulfonyl unit imparts specific electronic or structural properties.
• Chemical Biology & Proteomics: Employed in the design of activity-based probes (ABPs) and affinity labels to study enzyme function and protein interactions.
• Cross-Coupling Reactions: The chlorine atom is amenable to palladium-catalyzed cross-coupling, enabling further diversification of the pyridine core.
• Ligand & Catalyst Development: Useful for synthesizing novel chelating ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	6-Cyanopyridine-3-Sulfonyl Chloride
CAS No.	928139-31-5
Molecular Formula	C6H3ClN2O2S
Molecular Weight	202.62 g/mol
Synonyms	3-Pyridinesulfonyl chloride, 6-cyano-; 6-Cyano-3-pyridinesulfonyl chloride; 2-Cyanopyridine-5-sulfonyl chloride; 5-(Chlorosulfonyl)picolinonitrile; 6-Cyano-pyridine-3-sulfonyl chloride; Picolinonitrile-5-sulfonyl chloride; 5-Cyanopyridine-2-sulfonyl chloride (isomer reference)
EINECS	Contact for details

Quality Control

Every batch of 6-Cyanopyridine-3-Sulfonyl Chloride is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and FTIR, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.