Description

Raf265 (Chir-265) is a potent and selective small molecule inhibitor primarily used in biochemical and pharmacological research. This compound is of significant interest for its role in studying specific signaling pathways and cellular processes. It is a critical tool for researchers and developers in the pharmaceutical and biotechnology sectors, particularly those focused on oncology and kinase-targeted therapies. The product is supplied with the CAS registry number 927880-90-8.

Application

• Biochemical Research: Used as a reference standard and active agent in enzymatic assays to study kinase inhibition and signal transduction mechanisms.
• Pharmaceutical R&D: Serves as a key intermediate or lead compound in the discovery and development of novel therapeutic agents targeting specific kinases.
• Cell Biology Studies: Applied in cell-based experiments to investigate the effects of pathway inhibition on cell proliferation, apoptosis, and other phenotypic changes.
• Preclinical Development: Utilized in animal model studies to evaluate the efficacy, pharmacokinetics, and pharmacodynamics of potential drug candidates.
• Academic Research: A vital reagent for universities and research institutes exploring fundamental biological processes and disease models.
• High-Throughput Screening (HTS): Employed as a control compound in screening libraries to identify new bioactive molecules.

Basic Information

Product Name	Raf265 (Chir-265)
CAS No.	927880-90-8
Molecular Formula	C₂₃H₂₀ClN₅O₂S
Molecular Weight	473.96 g/mol
Synonyms	RAF265; CHIR-265; TAK-632; N-[3-[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-methylphenyl]-3-(trifluoromethyl)benzamide; 3-(Trifluoromethyl)-N-[3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]-4-methylphenyl]benzamide; B-Raf inhibitor RAF265; CHIR265
EINECS	Contact for details

Quality Control

Our Raf265 (Chir-265) is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination and NMR/LC-MS for structural confirmation. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere or in a desiccator to prevent degradation. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.