Description

(2-Chloro-6-Fluorophenyl)Methanesulfonyl Chloride is a high-purity, reactive sulfonyl chloride derivative of significant importance in advanced organic synthesis. Its primary value lies in its role as a versatile and critical building block for constructing complex molecules, particularly in the pharmaceutical and agrochemical sectors. This compound is essential for research chemists and process development scientists working on the synthesis of novel active ingredients, where it serves as a key intermediate for introducing the (2-chloro-6-fluorophenyl)methanesulfonyl functional group.

Application

This specialized intermediate is designed for high-value synthetic applications, primarily serving as a precursor in active pharmaceutical ingredient (API) development.

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, anti-inflammatory agents, and other therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of new generation herbicides, fungicides, and insecticides, where the chlorinated and fluorinated aromatic system confers specific biological activity.
• Chemical Research & Development: Employed in academic and industrial R&D labs for exploring new synthetic methodologies and creating complex molecular architectures for material science or medicinal chemistry.
• Sulfonamide & Sulfonate Ester Formation: The reactive sulfonyl chloride group enables efficient conversion to a wide range of sulfonamides (via reaction with amines) and sulfonate esters (via reaction with alcohols), expanding its utility in library synthesis.

Basic Information

Product Name	(2-Chloro-6-Fluorophenyl)Methanesulfonyl Chloride
CAS No.	926257-07-0
Molecular Formula	C7H5Cl2FO2S
Molecular Weight	243.08 g/mol
Synonyms	2-Chloro-6-fluorobenzylsulfonyl chloride; (2-Chloro-6-fluorophenyl)methanesulfonyl chloride; 1-(Chlorosulfonyl)methyl-2-chloro-3-fluorobenzene; α-Chlorosulfonyl-2-chloro-6-fluorotoluene; 2-Chloro-6-fluoro-α-(chlorosulfonyl)toluene; 2-Chloro-6-fluorobenzyl chloride sulfone; Methanesulfonyl chloride, (2-chloro-6-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our production of (2-Chloro-6-Fluorophenyl)Methanesulfonyl Chloride adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity and identity confirmation via NMR and IR spectroscopy. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to prevent hydrolysis. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Any single impurity ≤ 1.0%; Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.