Description

1,3,6-Trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonyl chloride is a high-purity, reactive sulfonyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to act as a versatile sulfonylation reagent, enabling the efficient introduction of the sulfonyl functional group into complex molecular architectures. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially in medicinal chemistry programs targeting enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides requiring specific sulfonamide functionalities.
• Peptide Modification: Employed as a sulfonylating agent for modifying amino acid side chains or protecting groups in peptide synthesis.
• Material Science Research: Serves as a precursor for creating functionalized polymers or organic electronic materials with sulfonyl groups.
• Chemical Biology Probes: Utilized in the development of activity-based probes (ABPs) for studying enzyme function and mechanism.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1,3,6-Trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonyl chloride
CAS No.	926199-52-2
Molecular Formula	C7H9ClN2O4S
Molecular Weight	252.67 g/mol
Synonyms	5-(Chlorosulfonyl)-1,3,6-trimethyl-2,4(1H,3H)-pyrimidinedione; 1,3,6-Trimethyl-5-(chlorosulfonyl)uracil; 5-(Chlorosulfonyl)-1,3,6-trimethyluracil; TMU-SO2Cl; Uracil-5-sulfonyl chloride, 1,3,6-trimethyl-; NSC 405124; 1,3,6-Trimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5-pyrimidinesulfonyl chloride
EINECS	Contact for details

Quality Control

Our production of 1,3,6-Trimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonyl chloride adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and IR spectroscopy, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic nature, the container should be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.