Description

Ku-60019 is a potent and selective small molecule inhibitor of ATM (Ataxia Telangiectasia Mutated) kinase, a key regulator of the DNA damage response. This compound is a critical research tool for studying cellular responses to genotoxic stress, DNA repair mechanisms, and their roles in oncology and radiobiology. It is primarily utilized by researchers in academic institutions, pharmaceutical R&D, and biotechnology companies focused on cancer biology, drug discovery, and radiobiology.

Application

• Cancer Research: Used to study the role of ATM in tumorigenesis, cancer cell survival, and as a potential chemosensitizer or radiosensitizer in therapeutic strategies.
• DNA Damage Response (DDR) Studies: A key pharmacological tool for dissecting the ATM-mediated signaling pathways in response to double-strand breaks and other DNA lesions.
• Radiobiology: Employed to investigate cellular radioresistance mechanisms and to explore strategies for enhancing the efficacy of radiotherapy.
• Neurodegenerative Disease Models: Used in research related to Ataxia-Telangiectasia and other neurological conditions linked to ATM dysfunction.
• Drug Discovery & Development: Serves as a reference compound and a starting point for the development of novel ATM inhibitors for therapeutic applications.
• Cell Cycle & Apoptosis Research: Facilitates studies on cell cycle checkpoints and programmed cell death pathways controlled by ATM activity.

Basic Information

Product Name	Ku-60019
CAS No.	925701-49-1
Molecular Formula	C₂₃H₂₀N₄O₃
Molecular Weight	400.43 g/mol
Synonyms	ATM Kinase Inhibitor Ku-60019; 2-Morpholino-N-(5-(6-morpholinopyridin-3-yl)pyridin-2-yl)-6-oxo-4-(trifluoromethyl)-1,6-dihydropyrimidine-5-carboxamide; Ku60019; KU-60019; ATM Inhibitor, Ku-60019; 6-Oxo-4-(trifluoromethyl)-1,6-dihydropyrimidine-5-carboxamide, 2-morpholino-N-[5-[6-(4-morpholinyl)-3-pyridinyl]-2-pyridinyl]-
EINECS	Contact for details

Quality Control

Our Ku-60019 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.