Description

Akt Inhibitor X CAS NO 925681-41-0 is a potent and selective small molecule inhibitor of the Akt (Protein Kinase B) signaling pathway, a critical regulator of cell survival, growth, and metabolism. This compound is an essential research tool for studying oncogenesis, cellular signaling networks, and developing novel therapeutic strategies for cancer and metabolic diseases. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in target validation, drug discovery, and preclinical studies.

Application

• Biochemical Research: Used as a selective probe to investigate the role of Akt isoforms (Akt1, Akt2, Akt3) in cellular signaling pathways.
• Oncology Research: Critical for in vitro and in vivo studies targeting cancers driven by PI3K/Akt/mTOR pathway dysregulation, such as breast, prostate, and ovarian cancers.
• Drug Discovery & Development: Serves as a reference compound or lead structure for the design and screening of novel Akt inhibitors in high-throughput screening (HTS) campaigns.
• Cell Biology Studies: Applied to elucidate mechanisms of cell proliferation, apoptosis (programmed cell death), and glucose metabolism.
• Preclinical Model Validation: Used in animal models to assess the efficacy and pharmacodynamics of inhibiting the Akt pathway for therapeutic potential.

Basic Information

Product Name	Akt Inhibitor X
CAS No.	925681-41-0
Molecular Formula	C₂₀H₂₅N₅O₃
Molecular Weight	383.45 g/mol
Synonyms	AKT inhibitor VIII; Akti-1/2; 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one; 9-Phenyl-8-[4-(1-aminocyclobutyl)phenyl]-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one; Akt Inhibitor VIII; CAS 925681-41-0
EINECS	Contact for details

Quality Control

Our Akt Inhibitor X is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation by spectroscopic methods. A detailed Certificate of Analysis (COA), documenting purity, assay, and impurity profiles, is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.