Description

4-(2H-Tetrazol-5-Yl)Benzenesulfonyl Chloride CAS NO 924964-20-5 is a high-value, heterocyclic sulfonyl chloride derivative that serves as a critical building block in advanced organic synthesis. Its core value lies in its dual functionality, combining a reactive sulfonyl chloride group with a tetrazole moiety, enabling its use in the creation of complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), bioactive compounds, and novel materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of drug candidates, especially those containing sulfonamide or tetrazole pharmacophores for targets like carbonic anhydrase or angiotensin II receptors.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the tetrazole ring contributes to biological activity and metabolic stability.
• Material Science Research: Employed in the creation of specialty polymers, ligands for metal-organic frameworks (MOFs), and advanced functional materials.
• Chemical Biology & Proteomics: Acts as a versatile reagent for bioconjugation, labeling biomolecules, or developing activity-based probes (ABPs) due to its reactive sulfonyl chloride group.
• Peptide Modification: Facilitates the site-specific sulfonylation of amino groups in peptides and proteins for structural studies or to alter physicochemical properties.
• Library Synthesis for Drug Discovery: A valuable scaffold in combinatorial and parallel synthesis for generating diverse compound libraries for high-throughput screening (HTS).

Basic Information

Product Name	4-(2H-Tetrazol-5-Yl)Benzenesulfonyl Chloride
CAS No.	924964-20-5
Molecular Formula	C7H5ClN4O2S
Molecular Weight	244.66 g/mol
Synonyms	5-(4-Chlorosulfonylphenyl)-1H-tetrazole; 4-(1H-Tetrazol-5-yl)benzenesulfonyl chloride; 5-(4-Chlorosulfonylphenyl)tetrazole; 1H-Tetrazole-5-carboxylic acid, 4-(chlorosulfonyl)phenyl ester; Tetrazole-5-benzenesulfonyl chloride; p-(Tetrazol-5-yl)benzenesulfonyl chloride; 4-(Tetrazol-5-yl)phenylsulfonyl chloride; Benzenesulfonyl chloride, 4-(2H-tetrazol-5-yl)-
EINECS	Contact for details

Quality Control

Our 4-(2H-Tetrazol-5-Yl)Benzenesulfonyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.