Description

Sar407899 is a high-purity, small molecule chemical compound identified by CAS number 923359-38-0. This compound is valued in research and development for its role as a potent and selective inhibitor of Rho-associated protein kinase (ROCK), a key enzyme involved in regulating cellular processes like cytoskeletal dynamics and smooth muscle contraction. It is primarily needed by pharmaceutical researchers, biotechnology companies, and academic institutions engaged in cardiovascular disease research, neurological studies, and the development of novel therapeutics targeting ROCK-mediated pathways.

Application

• Pharmacological Research: Used as a critical reference standard and active pharmaceutical ingredient (API) in preclinical studies investigating ROCK inhibition.
• Cardiovascular Disease Models: Applied in research targeting hypertension, atherosclerosis, and pulmonary arterial hypertension due to its vasodilatory effects.
• Neurological Disorder Studies: Utilized in models of stroke, spinal cord injury, and neurodegenerative diseases to examine neuroprotection and axonal regeneration.
• Cell Biology & Signaling Pathways: Serves as a precise tool to study the role of the Rho/ROCK pathway in cell migration, adhesion, and proliferation.
• Ophthalmic Research: Investigated for potential applications in treating glaucoma and other conditions related to intraocular pressure and retinal function.
• Drug Discovery & Development: Acts as a lead compound or intermediate in the synthesis and optimization of new therapeutic agents.

Basic Information

Product Name	Sar407899
CAS No.	923359-38-0
Molecular Formula	C₂₀H₂₀FN₅O₂
Molecular Weight	381.41 g/mol
Synonyms	SAR-407899; (R)-2-(2-(Difluoromethoxy)phenyl)-1-(4-((6-methyl-2-(methylamino)pyrimidin-4-yl)oxy)phenyl)ethyl carbamate; ROCK Inhibitor SAR407899; Carbamic acid, N-[(1R)-2-[2-(difluoromethoxy)phenyl]-1-[4-[(6-methyl-2-(methylamino)-4-pyrimidinyl)oxy]phenyl]ethyl]-, (9CI)
EINECS	Contact for details

Quality Control

Our Sar407899 is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, cool, and well-ventilated area. Keep the container sealed to protect this light-sensitive material from moisture and atmospheric contaminants.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.