Description

Irofulven is a potent, semi-synthetic sesquiterpene analog derived from the fungus Omphalotus illudens. This compound is a key investigational agent in oncology research, valued for its unique mechanism of action that induces apoptosis in cancer cells. It is primarily utilized by pharmaceutical R&D departments, academic research institutions, and biotechnology companies engaged in the development of novel chemotherapeutic agents. Irofulven CAS NO 920014-72-8 represents a critical tool for advancing studies in targeted cancer therapy and drug resistance mechanisms.

Application

• Oncology Drug Discovery & Development: As a core investigational new drug (IND) candidate for various solid tumors.
• Preclinical Cancer Research: Used in in vitro and in vivo studies to evaluate efficacy, pharmacokinetics, and mechanism of action.
• Biochemical Pathway Analysis: A tool for studying apoptosis induction, DNA damage response, and cell cycle arrest in malignant cells.
• Combination Therapy Studies: Research into synergistic effects with other chemotherapeutic agents or radiotherapy.
• Reference Standard: Serves as a high-purity analytical standard for quality control and bioanalytical method development in pharmaceutical manufacturing.
• Target Validation: Used in molecular biology to validate novel cancer targets and pathways.

Basic Information

Product Name	Irofulven
CAS No.	920014-72-8
Molecular Formula	C15H18O4
Molecular Weight	262.30 g/mol
Synonyms	6-Hydroxymethylacylfulvene; HMAF; MGI 114; NSC 683863; Acylfulvene analog; (1S,4R,6R)-4-Hydroxy-6-[(1S)-1-hydroxyethyl]-3-methyl-3-cyclohexene-1-carboxaldehyde; Illudin S analog
EINECS	Contact for details

Quality Control

Our Irofulven is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and stringent controls for residual solvents and impurities. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 10 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.