Description

Ethyl 2-(Difluoromethyl)-6-Hydroxynicotinate is a high-value fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its unique difluoromethyl and hydroxynicotinate structure makes it a versatile intermediate for creating complex molecules with enhanced biological activity and metabolic stability. This compound is essential for R&D and production chemists in the pharmaceutical and agrochemical industries, particularly for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the development of new-generation herbicides and fungicides, where the difluoromethyl group can improve efficacy and environmental profile.
• Chemical Research & Development: A valuable scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and lead optimization.
• Material Science Precursor: Potential intermediate for synthesizing specialty chemicals and functional materials, such as ligands for catalysis or fluorinated polymers.

Basic Information

Product Name	Ethyl 2-(Difluoromethyl)-6-Hydroxynicotinate
CAS No.	919354-84-0
Molecular Formula	C9H9F2NO3
Molecular Weight	217.17 g/mol
Synonyms	Ethyl 6-hydroxy-2-(difluoromethyl)nicotinate; 6-Hydroxy-2-(difluoromethyl)nicotinic Acid Ethyl Ester; 2-(Difluoromethyl)-6-hydroxynicotinic Acid Ethyl Ester; Ethyl 2-(Difluoromethyl)-6-oxo-1,6-dihydropyridine-3-carboxylate; 919354-84-0; Nicotinic acid, 2-(difluoromethyl)-6-hydroxy-, ethyl ester
EINECS	Contact for details

Quality Control

Our Ethyl 2-(Difluoromethyl)-6-Hydroxynicotinate is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for synthetic applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound may be hygroscopic; keep the container tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.