Description

Lck Inhibitor Ii CAS NO 918870-43-6 is a potent and selective small molecule inhibitor of the Lymphocyte-specific protein tyrosine Kinase (Lck), a key signaling molecule in T-cell activation. This compound is a critical research tool for investigating T-cell receptor signaling pathways and their role in immune regulation and autoimmune diseases. It is primarily utilized by pharmaceutical researchers, academic institutions, and biotechnology companies engaged in immunology, oncology, and inflammatory disease research.

Application

• Biochemical Research: Used as a selective probe to study Lck kinase activity and its downstream signaling cascades in T-cell development and function.
• Immunology Studies: Essential for investigating the mechanisms of T-cell activation, anergy, and tolerance in models of autoimmune disorders like rheumatoid arthritis and lupus.
• Drug Discovery & Development: Serves as a reference compound or a starting point for the design and screening of novel immunomodulatory and immunosuppressive therapeutics.
• Oncology Research: Applied in studies exploring the role of Lck in T-cell leukemias and lymphomas, aiding in target validation.
• Cellular Assay Development: Used to establish and validate high-throughput screening (HTS) assays for identifying new Lck inhibitors.
• Signal Transduction Pathways: A key reagent for dissecting the complex interplay between Src-family kinases and other intracellular signaling networks.

Basic Information

Product Name	Lck Inhibitor Ii
CAS No.	918870-43-6
Molecular Formula	C₂₀H₂₀N₆O₂S
Molecular Weight	408.48 g/mol
Synonyms	Lck Inhibitor II; 4-[(2,6-Dichlorophenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrile; A-420983; Lck Inhibitor (A-420983); Lck Kinase Inhibitor II; 6,7-Dimethoxy-4-((2,6-dichlorophenyl)amino)quinoline-3-carbonitrile; 4-[(2,6-Dichloroanilino)]-6,7-dimethoxyquinoline-3-carbonitrile
EINECS	Contact for details

Quality Control

Our Lck Inhibitor II is manufactured under strict quality systems to ensure batch-to-batch consistency and reliability for critical research applications. Each lot undergoes comprehensive analytical characterization, including purity verification by HPLC and structural confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C under desiccated conditions. Allow the product to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	Off-white to yellow solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.