Description

6-Bromo-3-Fluoro-2-(Hydroxymethyl)Pyridine is a high-value, multi-functional heterocyclic building block of significant interest in advanced organic synthesis. Its molecular architecture, featuring a bromo and a fluoro substituent on a hydroxymethylated pyridine core, makes it a versatile precursor for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity of halogenated pyridine derivatives.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers and organic electronic materials due to its modifiable hydroxymethyl group.
• Cross-Coupling Reactions: The bromo substituent is an excellent handle for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorinated Compound Libraries: An essential building block for medicinal chemistry teams constructing fluorinated compound libraries to explore structure-activity relationships (SAR).

Basic Information

Product Name	6-Bromo-3-Fluoro-2-(Hydroxymethyl)Pyridine
CAS No.	918793-01-8
Molecular Formula	C6H5BrFNO
Molecular Weight	206.01 g/mol
Synonyms	2-(Hydroxymethyl)-6-bromo-3-fluoropyridine; 3-Fluoro-6-bromo-2-pyridinemethanol; 6-Bromo-3-fluoro-2-pyridinemethanol; (6-Bromo-3-fluoro-2-pyridinyl)methanol; 2-Pyridinemethanol, 6-bromo-3-fluoro-; 918793-01-8
EINECS	Contact for details

Quality Control

Our 6-Bromo-3-Fluoro-2-(Hydroxymethyl)Pyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting regulatory filings for research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.