Description

Plx-4720 is a potent and selective small-molecule inhibitor of the B-Raf V600E oncogenic mutant, a key target in oncology research. This compound is crucial for investigating the MAPK/ERK signaling pathway, which is frequently dysregulated in various cancers, particularly melanoma. It serves as an essential research tool for academic institutions, pharmaceutical R&D departments, and biotechnology companies focused on developing targeted cancer therapies and understanding drug resistance mechanisms.

Application

• Biochemical Research: Used as a selective inhibitor to study the structure, function, and signaling dynamics of the B-Raf V600E kinase in vitro.
• Cancer Biology Studies: A critical tool for investigating the role of the MAPK/ERK pathway in tumor cell proliferation, survival, and metastasis.
• Drug Discovery & Development: Employed in high-throughput screening (HTS), lead optimization, and as a reference compound in preclinical studies for novel oncology therapeutics.
• Mechanism of Action (MoA) Studies: Utilized to elucidate the mechanisms of drug resistance and to identify potential combination therapies in cancer models.
• Cell-Based Assays: Applied in functional cellular assays to assess the efficacy and specificity of B-Raf inhibition on cancer cell lines.

Basic Information

Product Name	Plx-4720
CAS No.	918505-84-7
Molecular Formula	C₁₇H₁₄BrF₂N₃O₃
Molecular Weight	426.21 g/mol
Synonyms	PLX-4720; PLX 4720; PLX4720; Vemurafenib analog; 6-[5-[(4-Bromo-2-fluorophenyl)amino]-4-pyrimidinyl]-2,2-dimethyl-2,3-dihydro-7-benzofuranol; B-Raf(V600E) inhibitor; Raf inhibitor PLX4720; (R)-N-(3-(5-(4-Bromo-2-fluorophenylamino)-4-pyrimidinyl)-2-oxo-2,3-dihydro-1H-indol-5-yl)propane-1-sulfonamide (related analog name)
EINECS	Contact for details

Quality Control

Our Plx-4720 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting identity, purity, and other critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; sparingly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.