Description

3-(5-Fluoropyridin-2-Yl)Acrylic Acid Hydrochloride is a high-purity fluorinated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a reactive acrylic acid moiety attached to a fluoropyridine scaffold, enabling the construction of complex molecules for pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists working on novel active ingredients, particularly in the development of kinase inhibitors and other targeted therapies.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of novel drug candidates, especially kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in creating advanced active ingredients for crop protection products, leveraging the bioactivity of the fluoropyridine group.
• Chemical Biology Probe Development: Serves as a versatile handle for synthesizing fluorescent tags or affinity probes to study biological pathways.
• Material Science Research: Potential monomer or precursor for specialty polymers and functional materials due to its conjugated system.
• Cross-Coupling Reactions: The acrylic acid group can be utilized in various palladium-catalyzed cross-coupling reactions to create diverse chemical libraries.

Basic Information

Product Name	3-(5-Fluoropyridin-2-Yl)Acrylic Acid Hydrochloride
CAS No.	917760-91-9
Molecular Formula	C8H7ClFNO2
Molecular Weight	203.60 g/mol
Synonyms	(E)-3-(5-Fluoropyridin-2-yl)acrylic acid hydrochloride; trans-3-(5-Fluoropyridin-2-yl)-2-propenoic acid hydrochloride; 2-Propenoic acid, 3-(5-fluoro-2-pyridinyl)-, hydrochloride, (2E)-; 5-Fluoro-2-pyridineacrylic acid hydrochloride; 3-(5-Fluoropyridin-2-yl)propenoic acid HCl; (E)-3-(5-Fluoropyridin-2-yl)acrylic acid HCl salt
EINECS	Contact for details

Quality Control

Our 3-(5-Fluoropyridin-2-Yl)Acrylic Acid Hydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided for full traceability and quality assurance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.