Description

2-Fluoro-3-Iodotoluene is a halogenated aromatic building block of significant importance in advanced organic synthesis. Its value lies in the strategic positioning of fluorine and iodine atoms on the toluene ring, enabling sequential cross-coupling reactions and facilitating the construction of complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical, agrochemical, and materials science industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and iodinated aromatic cores for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and pesticides, where the introduction of fluorine can improve biological activity and environmental persistence.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis, such as palladium-catalyzed cross-couplings (Suzuki, Sonogashira).
• Material Science Research: Employed in the creation of organic electronic materials, liquid crystals, and polymers where halogenated aromatic units tune electronic properties and molecular packing.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags, as the iodine atom allows for further functionalization via radioiodination or other bioconjugation techniques.
• Custom Synthesis and Contract Manufacturing: A valuable substrate for fine chemical and custom synthesis organizations serving the life sciences sector.

Basic Information

Product Name	2-Fluoro-3-Iodotoluene
CAS No.	916420-21-8
Molecular Formula	C7H6FI
Molecular Weight	236.03 g/mol
Synonyms	1-Fluoro-2-iodo-3-methylbenzene; 3-Methyl-2-fluoro-1-iodobenzene; 2-Fluoro-3-iodo-1-methylbenzene; Toluene, 2-fluoro-3-iodo-; 2-Fluoro-3-iodotoluene; 3-Iodo-2-fluorotoluene; (2-Fluoro-3-iodophenyl)methane; 2-Fluoro-α-iodo-3-xylene (incorrect but common search variant).
EINECS	Contact for details

Quality Control

Our 2-Fluoro-3-Iodotoluene is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.