Description

2-Trifluoromethyl-Isonicotinonitrile CAS NO 916210-02-1 is a high-value fluorinated pyridine derivative, a crucial building block in advanced organic synthesis. Its unique trifluoromethyl and nitrile functional groups make it an indispensable intermediate for creating complex molecules with enhanced biological activity and physicochemical properties. This compound is primarily sought by pharmaceutical and agrochemical R&D teams for the development of novel active ingredients, including potential drugs and crop protection agents.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and infectious diseases.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity, metabolic stability, and overall efficacy.
• Ligand and Catalyst Development: Serves as a precursor for synthesizing specialized ligands and catalysts used in cross-coupling reactions and other transition metal-catalyzed processes.
• Material Science Research: Employed in the synthesis of advanced organic materials, such as liquid crystals, organic semiconductors, and polymers with specific electronic properties.
• Chemical Biology Probe Synthesis: Utilized to build molecular probes for studying enzyme function and biological pathways, leveraging its ability to be incorporated into more complex bioactive structures.

Basic Information

Product Name	2-Trifluoromethyl-Isonicotinonitrile
CAS No.	916210-02-1
Molecular Formula	C7H3F3N2
Molecular Weight	172.11 g/mol
Synonyms	4-Cyano-2-(trifluoromethyl)pyridine; 2-(Trifluoromethyl)isonicotinonitrile; 2-(Trifluoromethyl)-4-pyridinecarbonitrile; 4-Pyridinecarbonitrile, 2-(trifluoromethyl)-; Isonicotinonitrile, 2-trifluoromethyl-
EINECS	Contact for details

Quality Control

Every batch of 2-Trifluoromethyl-Isonicotinonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and GC-MS is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.