Description

1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-5-Fluoro- is a high-value halogenated heterocyclic building block essential for modern pharmaceutical and agrochemical research. This compound serves as a critical intermediate in the synthesis of complex molecules, particularly in the development of kinase inhibitors and other targeted therapeutics. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries for constructing novel active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of kinase inhibitors, anticancer agents, and other small-molecule drugs targeting various disease pathways.
• Agrochemical Research: Used in the discovery and development of new herbicides, fungicides, and insecticides, leveraging its unique halogenated pyrrolopyridine scaffold.
• Material Science: Serves as a precursor for organic electronic materials, such as ligands for OLEDs or conductive polymers, due to its fused aromatic structure.
• Chemical Biology: Employed as a molecular probe or a tagged fragment in medicinal chemistry for structure-activity relationship (SAR) studies and hit-to-lead optimization.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing advanced intermediates for clients.

Basic Information

Product Name	1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-5-Fluoro-
CAS No.	916177-01-0
Molecular Formula	C7H4BrFN2
Molecular Weight	215.02 g/mol
Synonyms	4-Bromo-5-fluoro-1H-pyrrolo[2,3-b]pyridine; 4-Bromo-5-fluoro-7-azaindole; 4-Bromo-5-fluoro-1H-7-azaindole; 5-Fluoro-4-bromo-1H-pyrrolo[2,3-b]pyridine; 5-Fluoro-4-bromo-7-azaindole; 7-Azaindole, 4-bromo-5-fluoro-; 1H-Pyrrolo[2,3-b]pyridine, 4-bromo-5-fluoro-
EINECS	Contact for details

Quality Control

Our 1H-Pyrrolo[2,3-B]Pyridine, 4-Bromo-5-Fluoro- is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white powder or crystalline solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.