Description

2-(Chloromethyl)-5-Fluoropyridine is a versatile and high-value halogenated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its molecular structure, featuring both a reactive chloromethyl group and a fluorine substituent on the pyridine ring, makes it an essential intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting the central nervous system and oncology.
• Agrochemical Synthesis: Used to construct novel herbicides, fungicides, and insecticides, leveraging the bioactivity of the fluoropyridine moiety.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of advanced organic materials, including liquid crystals and functional polymers.
• Chemical Biology Probes: Utilized to create tagged molecules or probes for studying biological systems and drug-target interactions.
• Custom Synthesis and Contract Manufacturing: A fundamental building block for custom synthesis projects and scale-up processes in fine chemical production.

Basic Information

Product Name	2-(Chloromethyl)-5-Fluoropyridine
CAS No.	915690-76-5
Molecular Formula	C6H5ClFN
Molecular Weight	145.56 g/mol
Synonyms	5-Fluoro-2-(chloromethyl)pyridine; 2-Chloromethyl-5-fluoropyridine; (5-Fluoropyridin-2-yl)methyl chloride; 5-Fluoro-2-pyridinemethyl chloride; 2-Pyridinemethanol, 5-fluoro-, chloride; 915690-76-5; 5-Fluoro-2-chloromethylpyridine
EINECS	Contact for details

Quality Control

Every batch of 2-(Chloromethyl)-5-Fluoropyridine is manufactured and tested under a strict quality management system to ensure consistency and reliability for your synthetic processes. We provide comprehensive Certificates of Analysis (COA) that detail purity, identity, and impurity profiles, typically determined by HPLC, GC, NMR, and IR spectroscopy. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Single Unknown Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.