Description

Indimitecan is a high-purity pharmaceutical intermediate and research chemical with the CAS registry number 915360-05-3. This compound is of significant interest for its role in the synthesis and development of novel therapeutic agents, particularly in oncology research. It is essential for pharmaceutical R&D laboratories, academic research institutions, and manufacturers of active pharmaceutical ingredients (APIs) seeking reliable, high-quality building blocks for complex synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced camptothecin analogs and other topoisomerase I inhibitors for cancer therapy.
• Oncology Research: Used in preclinical and discovery-phase studies to investigate new mechanisms of action and develop next-generation chemotherapeutic agents.
• Active Pharmaceutical Ingredient (API) Development: Serves as a critical precursor in the multi-step manufacturing process of targeted cancer drugs.
• Biochemical Research: Employed as a reference standard or probe compound in studies of DNA replication, cell cycle arrest, and apoptosis.
• Process Chemistry & Scale-Up: Utilized by process development teams to optimize synthetic routes for commercial-scale API production.

Basic Information

Product Name	Indimitecan
CAS No.	915360-05-3
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	7-Ethyl-10-hydroxycamptothecin derivative; Indimitecan; 7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecin; (S)-10-[(1-Piperidino)(4-piperidino)carbonyloxy]-7-ethylcamptothecin; SN-38 derivative; Topoisomerase I inhibitor intermediate; Camptothecin analog 915360-05-3
EINECS	Contact for details

Quality Control

Our Indimitecan is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and impurity profiling, to meet the stringent requirements of pharmaceutical development. A Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Off-white to light yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Unknown Impurity	≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.