Description

Ido-In-1 is a potent and selective small molecule inhibitor of the indoleamine 2,3-dioxygenase 1 (IDO1) enzyme, a key regulator of immune tolerance. This compound is crucial for advancing research in immuno-oncology and autoimmune diseases by modulating the kynurenine pathway. It is an essential research tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on developing novel immunotherapies and understanding tumor microenvironment dynamics.

Application

• Immuno-oncology Research: Used as a reference standard and tool compound to study IDO1 inhibition and its role in reversing tumor-mediated immune suppression.
• Drug Discovery & Development: Serves as a key intermediate or active pharmaceutical ingredient (API) in the preclinical development of novel immunotherapeutic agents.
• Biochemical Assays: Employed in high-throughput screening (HTS) and enzymatic assays to evaluate the potency and selectivity of new IDO1 inhibitors.
• Mechanistic Studies: Facilitates research into the kynurenine pathway's impact on T-cell function, dendritic cell activity, and overall immune response modulation.
• In Vitro & In Vivo Models: Applied in cell-based studies and animal models to investigate the therapeutic potential of IDO1 blockade in cancer and inflammatory diseases.

Basic Information

Product Name	Ido-In-1
CAS No.	914638-30-5
Molecular Formula	C₁₉H₁₇N₅O₂
Molecular Weight	347.37 g/mol
Synonyms	1-Methyl-N-[6-(1-piperidinylmethyl)-1H-benzimidazol-2-yl]-1H-indole-5-carboxamide; IDO1 Inhibitor Ido-In-1; INCB024360 analog; Epacadostat analog; IDO Inhibitor
EINECS	Contact for details

Quality Control

Our Ido-In-1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) with detailed chromatograms and spectral data are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.